Research Supervisor Connect

Pave the Road for Personalized Therapy in Alzheimer's Disease - Harnessing Advanced Neuroimaging to Map Neurobiological Heterogeneity.

Summary

This project aims to leverage advanced neuroimaging and AI-driven analysis to identify individual “brain fingerprints” of Alzheimer’s disease, enabling earlier detection and more precise, personalized therapeutic strategies.

Supervisor

Dr Jinglei Lv.

Research location

Biomedical Engineering

Synopsis

Alzheimer’s disease (AD) is highly heterogeneous, with patients showing diverse trajectories of cognitive decline, pathology, and treatment response. Current clinical tools fail to account for this neurobiological diversity, leading to inconsistent diagnoses and limited therapeutic success.

This project will apply state-of-the-art neuroimaging methodologies—including multimodal MRI (structural, diffusion, and functional imaging), lesion mapping, and connectomics—combined with machine learning approaches such as normative modelling and digital twin frameworks. By integrating large-scale imaging datasets (e.g., UK Biobank, ADNI, AIBL) with clinical and cognitive data, we aim to map distinct subtypes of AD, uncover early biomarkers, and predict disease progression on an individual level.

The ultimate goal is to translate these findings into clinically actionable tools that can guide precision therapies and improve patient outcomes.

Research techniques/technologies 

Multimodal MRI (T1, fMRI, DWI), connectomics, lesion mapping, machine learning (normative modelling, deep learning), digital twin modelling.

Offering

A scholarship for 3.5 years at the RTP stipend rate (currently $41,753 in 2025). International applicants will have their tuition fees covered.

Successful candidates must:

  • have a strong background in biomedical engineering, neuroscience, computer science, or related disciplines.
  • have experience with neuroimaging analysis, data science, or AI methods is desirable but not essential.
  • have an interest in precision medicine, brain health, and translational neuroscience.

How to apply:

To apply, please email [email protected] the following:

  • A detailed CV, including academic qualifications, research experience and publications
  • Academic transcripts

Want to find out more?

Opportunity ID

The opportunity ID for this research opportunity is 3688

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