Research Supervisor Connect

Developing decision algorithms for treatment sequencing in colorectal liver metastases

Summary

This project aims to create a clinical decision framework integrating molecular biomarkers, imaging, and patient factors to guide sequencing of chemotherapy and surgery in colorectal liver metastases.

Supervisor

Professor Thomas J Hugh.

Research location

North Shore - Kolling Institute of Medical Research

Synopsis

Despite advances in liver resection and systemic therapy, the optimal sequencing of chemotherapy and surgery for resectable colorectal liver metastases is still unclear. This project builds on ongoing translational work identifying proteomic and extracellular vesicle biomarkers predictive of chemotherapy response. The student will analyse existing institutional and collaborative datasets, integrating clinical, radiological, and molecular variables to develop and test predictive algorithms. The ultimate goal is to provide a personalised treatment pathway that improves survival and reduces futile therapy.

Additional information

Ideal for a candidate with an interest in surgical oncology, data analysis, and personalised medicine. Collaboration with the Kolling Institute and NSLHD Kolling Biobank ensures access to high-quality clinical and molecular data.

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Opportunity ID

The opportunity ID for this research opportunity is 3708

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