Research Supervisor Connect

Medicinal Chemistry and Biology - Development of Novel Anti-Tumour Agents for Cancer Treatment


This project is involved in the exciting development of novel drugs for the treatment of cancer and other conditions.


Professor Des Richardson.

Research location

Camperdown - School of Medical Sciences - Bosch Institute

Program type



This exciting project involves the design, synthesis and testing of novel drugs for the treatment of cancer and requires a student with an interest in pharmacology and medicinal chemistry. It includes the examination of structure-activity relationships and analysis of the mechanisms involved in their anti-cancer activity. The project uses techniques from a wide range of disciplines including cell and molecular biology, chemistry, physiology, pharmacology and biochemistry. This work follows on from exciting recent studies in our laboratory that have successfully identified a highly active group of anti-tumour agents that will enter clinical trials

  • Whitnall, M., Howard, J. Ponka, P. and Richardson, D.R. A class of iron chelators with a wide spectrum of potent anti-tumor activity that overcome resistance to chemotherapeutics. Proc. Natl. Acad. Sci. USA 2006;103:14901-6
  • Richardson, D.R., Sharpe, P.C., Lovejoy, D.B., Senaratne, D., Kalinowski, D.S., Islam, M., Bernhardt, P.V. (2006) Dipyridyl thiosemicarbazone chelators with potent and selective anti-tumor activity form iron complexes with marked redox activity. J. Med. Chem. 49(22):6510-6521).
A scholarship is available to support this project. Applicants must be Australian citizens, Australian permanent residents or New Zealand citizens. The scholarship stipend is equivalent to Australian Post-Graduate Award Rates.

Additional information


  • Ph.D Scholarships are available to high quality students.
Techniques: The work involves a wide range of modern techniques including:-
  • cell culture
  • molecular biology
  • X-ray crystallography
  • animal biology

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Opportunity ID

The opportunity ID for this research opportunity is 7